Division of Neurobiology
Division of Neurobiology - Phosphorylation of mTOR in neurons in the striatum
Division of Immunology and Pathogenesis
Division of Immunology and Pathogenesis - Salmonella typhimurium growing within a macrophage
Division of Cell and Developmental Biology
Division of Cell and Developmental Biology - Impaired trafficking of Notch in neoplastic ESCRT mutant Drosophila cells
Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Genetics, Genomics and Development - Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Biochemistry, Biophysics and Structural Biology
Division of Biochemistry, Biophysics and Structural Biology - Structure of the human Ndc80 kinetochore complex around microtubules

Recent News

MCB Professor of Immunology and Pathology Jeffery Cox with Nevan Krogan of UCSF and the Gladstone Institutes and other researchers, utilized mass spectrometry to target 34 Mycobacterium tuberculosis (Mtb) proteins inside human cells, enabling them to study 187 interactions between the human and tuberculosis proteins. Their paper, published in Molecular Cellhighlights creating an Mtb-human protein-protein interaction map and identifying a switch between host antiviral and antibacterial responses. 

The team hopes to target human host proteins involved in commonly hijacked pathways in human cells during the disease state, and develop new therapies that use a single drug to treat multiple pathogens - not only bacterial TB but viral infections and other diseases. 

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New research from the lab of MCB Associate Professor Diana Bautista demonstrates that a single molecule, sphingosine 1-phosphate (S1P), can cause both pain and itch in the skin of male mice. In the future, treatments that block the receptor for that molecule may control pain and itch sensations in those who suffer from certain skin diseases.

MCB graduate student Rose Hill is first author of the paper, published this week in The Journal of Neuroscience.

Hitomi Asahara and Alison Killilea were recently recognized for their contributions to the University with campus staff awards. Both scientists are directors of MCB research facilities and have found creative, innovative ways to improve or enhance their facilities. In turn, their work will help other UC Berkeley scientists perform their research more efficiently.

Recent MCB graduate Carolyn Elya, who studied with HHMI Investigator and Professor of GGD Michael Eisen, discovered a fungus that infects fruit flies, invades their nervous system, and manipulates the fly's behavior to its advantage. Infecting flies back in the lab, they were able to study how the E. Muscae pathogen infected the host and induced the behavioral changes. A paper was just published in eLife with their findings. 

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New Research from the lab of MCB Assistant Adjunct Professor and Scientific Director of the Innovative Genomics Initiative Jacob Corn sheds light on the 'black box' of how cells repair their DNA after the CRISPR-Cas9 enzyme makes its incision, and demonstrates that many of the common assumptions on how this repair occurs are incorrect.