Division of Neurobiology
Division of Neurobiology - Phosphorylation of mTOR in neurons in the striatum
Division of Cell and Developmental Biology
Division of Cell and Developmental Biology - Impaired trafficking of Notch in neoplastic ESCRT mutant Drosophila cells
Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Genetics, Genomics and Development - Heterochromatin dynamics in Saccharomyces cerevisiae
Division of Immunology and Pathogenesis
Division of Immunology and Pathogenesis - Salmonella typhimurium growing within a macrophage
Division of Biochemistry, Biophysics and Structural Biology
Division of Biochemistry, Biophysics and Structural Biology - Structure of the human Ndc80 kinetochore complex around microtubules

Recent News

On November 5, UC Berkeley hosted the 2019 Breakthrough Prize Symposium. The event hosts talks from some of the world's brightest minds at the forefront of fundamental physics, life sciences and mathematics.

Professor of MCB & Chemistry Jennifer Doudna, recipient of the 2015 Breakthrough Prize in life sciences, spoke on recent breakthroughs in CRISPR research. Her presentation, titled Recoding Life: The Future of Gene Editing, can be viewed here.

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MCB Professor Daniel Rokhsar has been appointed to the Marthella Foskett Brown Chair in Biological Sciences. The Chair supports faculty research in quantitative and systems biology.

 

Congratulations to MCB & Chemistry Professor Jennifer Doudna, who is one of five recipients of this year's Medal of Honor from the American Cancer Society! Medal of Honor recipients are "distinguished individuals who have made valuable contributions in the fight against cancer through basic research, clinical research and cancer control."

Professor Doudna joined four others in receiving the award at a ceremony today in Washington, DC: former Vice President Joe Biden, CRISPR co-inventor Emmanuelle Charpentier, geneticist Charis Eng, and cancer researcher Michael Thun.

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Two new publications from MCB Professor David Raulet and collaborators focus on the role of natural killer cells in anti-tumor responses. Natural killer cells are a type of white blood cell that have an important role in defending against virally infected cells and tumors.

The first, published in Journal of Clinical Investigation, demonstrated that checkpoint inhibitors, a well-established cancer immunotherapy, have the ability to activate natural killer cells. In the future, researchers hope to better understand the factors that influence natural killer cell activation for use in improved immunotherapies. Read more...

The second paper, published in Immunity, is a collaboration with the lab of MCB Professor Russell Vance. It shows that cGAMP from tumors promotes natural killer anti-tumor immune responses. Read more...

A new paper from the lab of Professor of MCB & Chemistry and HHMI Investigator Jennifer Doudna identifies and details the power of the smallest CRISPR system found to date, Cas14. CRISPR-Cas14 was first discovered in archaea with some of the smallest known genomes and is especially effective in editing viral genes or genes in small cells.

Due to its effectiveness in targeting and cutting single-stranded DNA, researchers have identified Cas14's potential use in improving rapid CRISPR diagnostic tests for ailments such as cancer and infectious diseases.

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