T
|
Jan 16 |
Overview of
key DB concepts/terms, syllabus & information HO
|
SLA |
Th
|
Jan 18 |
Overview of
key signaling pathways, signaling HO
|
SLA |
F
|
Jan 19 |
Discussion
section organizational meeting |
SLA |
|
|
|
|
T
|
Jan 23 |
Hemichordates
and chordates: AP axis |
JG |
Th
|
Jan 25 |
Hemichordates
and chordates: DV axis |
JG |
F
|
Jan 26 |
Discussion: Dorsoventral patterning in hemichordates:
Insights into early chordate evolution
|
jg/SD |
|
|
|
|
T
|
Jan 30 |
Sea urchin
development, extra reading
|
FW |
Th
|
Feb 1 |
Gene
regulatory networks in sea urchin embryos |
FW |
F
|
Feb 2
|
Discussion: Repression of mesodermal fate by foxa, a key endoderm regulator of
the sea urchin embryo
|
fw/JL |
|
|
|
|
T
|
Feb 6
|
Asymmetric
cell division |
GG |
Th
|
Feb 8
|
Cell migration
and axon guidance
|
GG |
F
|
Feb 9 |
Discussion: Wnt signals can function as positional cues in
establishing cell polarity
|
gg/KH |
|
|
|
|
T
|
Feb 13 |
Regulation of
growth during development, notes
|
IH |
Th
|
Feb 15 |
Patterning at
the level of single cells - the Drosophila eye, notes
|
IH |
F
|
Feb 16 |
Discussion: Regulation of cell proliferation by a
morphogen gradient
|
ih/MG |
|
|
|
|
T
|
Feb 20 |
Classical
experiments in amphibian embryology, extra
reading
|
RMH |
Th
|
Feb 22 |
Signaling
pathways in Xenopus embryos, movie links
|
RMH |
F
|
Feb 23 |
Discussion: Maternal Wnt1 activates the canonical Wnt
signaling pathway require for axis formation in Xenopus embryos
|
rmh/NH |
|
|
|
|
T
|
Feb 27 |
Xenopus
Spemann's Organizer, neural induction and patterning |
RMH |
Th
|
Mar 1
|
Morphogenesis:
gastrulation and neurulation in frog
|
RMH |
F
|
Mar 2 |
Discussion: Integrin alpha-5-beta-1 and fibronectin regulate
polarize cell protrusions require for Xenopus
convergence and extension
|
rmh/CM |
|
|
|
|
T
|
Mar 6
|
Mouse: early
development and morphogenesis |
RMH |
Th
|
Mar 8
|
Mouse: the
head organizer and the node |
RMH |
F
|
Mar 9 |
Discussion: Cell fate decision within the mouse organizer
are governed by graded Nodal signals
|
rmh/PG&DN |
F
|
Mar
9
|
Assignment #1 due before 5 pm |
|
|
|
|
|
T
|
Mar 13 |
Segmentation
of the Drosophila embryo |
ML |
Th
|
Mar 15 |
Dorsal-ventral
patterning and gastrulation in Drosophila |
ML |
F
|
Mar 16 |
Discussion: A self-organizing system of repressor gradients
establishes segmental complexity in Drosophila
|
ml/DR |
|
|
|
|
T
|
Mar 20 |
Dorsal-ventral
patterning and gastrulation in Drosophila, continued |
ML |
Th
|
Mar 22 |
Homeotic genes
in Drosophila and other arthropods |
ML |
F
|
Mar 23 |
Discussion: A core transcriptional network for early
mesoderm development in Drosophila
melanogaster
|
ml/MW |
|
|
|
|
| M-F, Mar 26-30, SPRING BREAK |
|
|
|
|
T
|
Apr 3 |
Gene
regulatory networks in flies |
ML |
Th
|
Apr 5 |
OPEN |
|
F
|
Apr 6 |
Discussion
(may be rescheduled) |
? |
|
|
|
|
T
|
Apr 10 |
Hematopoiesis
and Lymphocyte Development |
MS |
Th
|
Apr 12 |
Immunity in
Organisms without Lymphocytes |
MS |
F
|
Apr 13 |
Discussion: Assemling a gene regulatory network for
specification of the B cell fate
Background: PU.1 regulates expression of the
Interleukin-7 receptor in lyphoid progenitors
|
ms/AM |
|
|
|
|
T
|
Apr 17
|
Structure and
Function of the Stem Cell Niche |
AW |
Th
|
Apr 19 |
Neurogenesis
in the Central Nervous System |
AW |
F
|
Apr 20 |
Discussion: Postnatal deletion of Numb/Numblike reveals
repair and remodeling capacity in the subventricular neurogenic niche
Assignment: Assignment #2
|
aw/AC |
|
|
|
|
T
|
Apr 24 |
Early
zebrafish development |
SLA |
Th
|
Apr 26 |
Zebrafish
mesoderm development and axis formation |
SLA |
F
|
Apr 27 |
Discussion: Differential regulation of germline mRNAs in
soma and germ cells by zerbrafish miR-430 & Supplimental Data
|
sla/RR |
|
|
|
|
M
|
Apr 9
|
Assignment
#2 due by 10 am (or earlier)
|
|
T
|
May 1 |
Vertebrate
mesodermal segmentation; Somite patterning
|
SLA |
Th
|
May 3
|
D-V patterning
of the neural tube; Neural crest
|
SLA |
F
|
May 4
|
Discussion
|
sla/JE&AS
|